Do Multivitamins/Supplements Work?
A large percentage of Americans take some form of multivitamin (capsules, gummies, powders, tablets etc) as part of their daily health routine, but is it worth the money? Does our health benefit? Do multivitamins work?
The goal of a multivitamin isn’t just to avoid diseases of malnutrition like scurvy (vitamin C deficiency), but to boost vitamin and mineral intake up above the RDA in the context of an otherwise lower quality diet, with the assumption that doing so will reverse the increased risk of chronic disease associated with dietary insufficiency of these same nutrients.
However, even though a large percentage of Americans are vitamin deficient, studies repeatedly show multivitamin supplementation doesn’t do much for our health as compared to following a healthy diet. This is not to say that vitamin supplements are bad, just that we don’t see the expected benefits in studies.
Let’s take a look at the science regarding the effects of multivitamins.
A vast collection of high-quality studies (including clinical trials) have failed to show any protective impact from taking a daily multivitamin. Huge meta-analysis have shown that taking a multivitamin doesn’t equate to good health, that is, they don’t prevent health conditions. For instance, a meta-analysis conducted in 2013 revealed that multivitamin use had no discernible impact on all-cause mortality (a general indicator of health and longevity), or mortality related to cardiovascular disease. Similarly, a systematic review and meta-analysis from 2018 found that multivitamin/mineral supplements did not confer any benefits in terms of cardiovascular disease incidence or outcomes, including coronary heart disease and stroke. Furthermore, a systematic review conducted in 2013 found no evidence supporting the effectiveness of vitamin and mineral supplements in preventing cardiovascular disease or cancer.
Why Aren’t Multivitamins Effective?
If multivitamins were benefiting our health we would expect to see that reflected in the previous statistics but we don’t. Why? At this point, we don’t know for sure why multivitamins aren’t effective but there are several likely explanations. It could be that our diets are so insufficient on average that the amount of additional nutrients provided by multivitamins is not enough to make a difference or it could be that nutrients in multivitamins are poorly absorbed. It’s also possible that the chemical forms of the nutrients in a multivitamin are not as bioavailable (compared to forms in food) or don’t have the same synergy with other nutrients typically found together in foods. On the flip side, there could be more competitive binding in the forms found in a multivitamin, meaning we aren’t absorbing all of the nutrients. It’s also possible that there are important nutrients in foods that we don’t formulate into multivitamins which are the key difference (such as fiber, fatty acids, phytonutrients such as beta-carotene etc.) More than likely the reasons multivitamins don’t provide the same benefits, with respect to various medical conditions, as obtaining nutrients from the foods we eat, is some combination of the above or all of the above. While it’s possible there could be a well-formulated multivitamin out there that is capable of overcoming these issues, on average the science shows that multivitamins do not. And, since the Food and Drug Administration (FDA) does not regulate these supplements, the quality across multivitamins is not consistent.
Food Versus Multivitamin
A 2019 study compared the health outcomes associated with nutrients obtained from food versus those obtained from supplements, shedding light on this matter. The study demonstrated that adequate intake of vitamin A, vitamin K, magnesium, zinc, and copper from food sources—rather than supplements—reduced all-cause mortality and mortality related to cardiovascular disease. Conversely, excessive calcium intake from supplements— but not from food—was linked to an increased risk of cancer-related mortality. Moreover, supplemental calcium usage was associated with the formation of calcium oxalate kidney stones. Elevated serum levels of folic acid, a common form of vitamin B9 (folate) found in supplements, were associated with an increased risk of cancer and could mask vitamin B12 deficiency. These findings underscore the importance of obtaining nutrients primarily from food sources and highlight potential adverse effects of supplementation.
When to Supplement?
It’s crucial to emphasize that targeted supplementation, which is advised by healthcare professionals based on specific nutrient deficiencies identified through laboratory tests, remains an essential component of overall health management. There are numerous scenarios where nutritional supplements are warranted; for instance, prenatal vitamins have proven highly effective in minimizing the risk of neural tube defects such as spina bifida. Supplementation may also be advisable for older adults who experience age-related decreases in absorption of specific nutrients or for those following diets which limit access to specific nutrients, such as vegans or vegetarians. Supplementing with vitamin D can also be beneficial when testing shows we are deficient. That’s why it’s advisable to consult with a healthcare professional regarding the necessity of specific nutritional supplements based on your body needs. However, it’s essential to recognize that supplements cannot compensate for an overall diet lacking in essential nutrients. Bottom line – these studies strengthen the case for eating a well-balanced diet focused on nutrients (aka Nutrivore) and following a healthy lifestyle.
Check out this video where I share all my thoughts on multivitamins!
cITATIONS
Expand to see all scientific references for this article.
Chen F, Du M, Blumberg JB, Ho Chui KK, Ruan M, Rogers G, Shan Z, Zeng L, Zhang FF. Association Among Dietary Supplement Use, Nutrient Intake, and Mortality Among U.S. Adults: A Cohort Study. Ann Intern Med. 2019 May 7;170(9):604-613. doi: 10.7326/M18-2478. Epub 2019 Apr 9. PMID: 30959527; PMCID: PMC6736694.
Fortmann SP, Burda BU, Senger CA, Lin JS, Whitlock EP. Vitamin and mineral supplements in the primary prevention of cardiovascular disease and cancer: An updated systematic evidence review for the U.S. Preventive Services Task Force. Ann Intern Med. 2013 Dec 17;159(12):824-34. doi: 10.7326/0003-4819-159-12-201312170-00729. PMID: 24217421.
Kim J, Choi J, Kwon SY, McEvoy JW, Blaha MJ, Blumenthal RS, Guallar E, Zhao D, Michos ED. Association of Multivitamin and Mineral Supplementation and Risk of Cardiovascular Disease: A Systematic Review and Meta-Analysis. Circ Cardiovasc Qual Outcomes. 2018 Jul;11(7):e004224. doi: 10.1161/CIRCOUTCOMES.117.004224. PMID: 29991644.
Macpherson H, Pipingas A, Pase MP. Multivitamin-multimineral supplementation and mortality: a meta-analysis of randomized controlled trials. Am J Clin Nutr. 2013 Feb;97(2):437-44. doi: 10.3945/ajcn.112.049304. Epub 2012 Dec 19. PMID: 23255568.